Drug–Drug Interaction Studies: Regulatory Guidance and An Industry Perspective

Regulatory Guidance Documents on Adaptive Designs: An Industry Perspective

W. He et al. (eds.), Practical Considerations for Adaptive Trial Design and Implementation, Statistics for Biology and Health, DOI 10.1007/978-1-4939-1100-4_2, © Springer Science+Business Media New York 2014 Abstract Adaptive designs have the potential to be a transformative methodology in clinical drug development, but acceptance by regulatory agencies is a prerequisite for their broader adopt...

comparative dna interaction studies of antiviral drug, zidovudine and its complex using different instrumental methods

هدف از این مطالعه بررسی امکان استفاده از داروهای شناخته شده در درمان سایر بیماریها به عنوان داروهای ضد سرطان است. همچنین با استفاده از این داروها در ساختمان کمپلکس فلز می توان شاخص های دارویی بدست آمده را بررسی نمود. داروی ضد ویروس ایدز(hiv)به نام زیدوودین(azt)انتخاب و.کمپلکس.محلول.در.آب[pt(azt)2]cl2سنتزو به روشهای مختلف فیزیکی و شیمیایی شناسایی گردید. بر هم کنش مقایسه ای این دارو و کمپلکس پلا...

Transmyocardial revascularization: an industry perspective.

e s t e r d a y . The concept of what is now called transmyocardial revascularization actually precedes the evolution of coronary artery bypass (CABG) surgery and percutaneous transluminal coronary angioplasty (PTCA). Wearn described the myocardial microanatomy (most notably the arterioluminal sinusoids, which are poorly developed in humans but a major myocardial blood supply to reptiles) as ea...

HTA and value--an industry perspective.

defined as the health outcome achieved per dollar spent. " This infers that a lesser weighting should be given to those elements of value which are not directly related to patients receiving the technology such as wider societal benefits. Tunis and Eddy (3) introduced the concept of clinical and health policy decisions consisting of two critical components, namely evidence and then judgment. Th...

Knowledge Management from an Industry Perspective Knowledge Management from an Industry Perspective